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Some drugs that are commonly used this way are the anti-depressants called serotonin reuptake inhibitors, like venlafaxine (Effexor), and others.
Also, watch out for condoms or gels that contain nonoxynol-9 (N-9).
N-9 is a birth control agent that kills sperm, but it can irritate the vagina, especially if the tissues are already dry or fragile.
Before sex, put some lubricant around and inside the entrance of your vagina. If vaginal penetration lasts more than a few minutes, you may need to stop briefly and use more lubricant.
Petroleum jelly (Vaseline), skin lotions, and other oil-based lubricants are not good choices for vaginal lubrication.
In some women, they may raise the risk of yeast infection.
It’s important that any woman taking hormone therapy be checked each year by her provider.